Study of Interactions between DNA and Tetrapeptides Study of Interactions...
Tetrapeptide Lys-Glu-Asp-Trp is a mimetic of insulinotropic peptides and reduces the blood glucose level. This tetrapeptide increases the content of important factors of differentiation in endocrine...
View ArticleShort Peptides Stimulate Serotonin Expression in Cells of Brain Cortex
Peptides Glu-Asp-Arg and Lys-Glu-Asp stimulate serotonin expression in aging cultures of brain cortex cells. Peptide regulation of 5-tryptophan hydroxylase gene encoding the enzyme involved in...
View ArticlePeptides Regulate Expression of Signaling Molecules in Kidney Cell Cultures...
We studied the effect of polypeptide complex isolated from calf kidney and short peptides T-31 (AED) and T-35 (EDL) on the expression of signaling molecules, markers of cell renewal (Ki-67, p53),...
View ArticlePeptides Stimulate Expression of Signal Molecules in Neuronal Cultures from...
Molecular mechanisms of the neuroprotective effect of peptide T-33 and cortexin were studied on organotypic cultures of the brain from young and old Wistar rats. The effective concentration of peptide...
View ArticlePeptide bioregulators: A new class of geroprotectors, report 2. The results...
AbstractThis paper reviews the results of long-term studies by the authors on the clinical efficacy of peptide bioregulators (Timalin, Thymogen, Vilon, Epithalamin, Prostatilen, Cortexin, and...
View ArticlePeptide Regulation of Gene Expression and Protein Synthesis in Bronchial...
AbstractIntroductionSome studies have shown that peptides have high treatment potential due to their biological activity, harmlessness, and tissue-specific action. Tetrapeptide Ala-Asp-Glu-Leu (ADEL)...
View ArticlePeptides, genome, aging
AbstractDuring investigation of the mechanism of the action of short peptides, it was established that they regulate gene expression and protein synthesis. These peptides stimulate proliferation and...
View ArticleMolecular Aspects of Anti-Atherosclerotic Effects of Short Peptides
We studied molecular mechanisms of the vasoprotective effects of tripeptide T-38 and dipeptide RR-1. Short peptides T-38 and the RR-1 activate the processes of cell renewal in organotypic and...
View ArticleRole of Peptide Bond in the Realization of Biological Activity of Short Peptides
We performed a comparative analysis of biological activity of Lys-Glu peptide and its amino acid constituents. It was established that Lys-Glu stimulated proliferation of splenic cells in organotypic...
View ArticleEpigenetic mechanisms of peptidergic regulation of gene expression during...
AbstractExpression levels of genes encoding specific transcription factors and other functionally important proteins vary upon aging of pancreatic and bronchial epithelium cell cultures. The peptides...
View ArticlePeptides and CCL11 and HMGB 1 as molecular markers of aging: Literature...
AbstractCytokines CCL11 (eotaxin) and HMGB1 (alarmin 1) are molecular markers of ageing and neurological, cardiovascular, and immune diseases. Created at the St. Petersburg Institute of Bioregulation...
View ArticleShort peptides stimulate cell regeneration in skin during aging
AbstractThe search for new safe and efficient low-molecular weight substances stimulating skin regeneration is an important objective of geriatric cosmetology. The present study addressed the effects...
View ArticleEpigenetic aspects of peptidergic regulation of vascular endothelial cell...
AbstractShort peptides, vesugen and D-7, stimulated the synthesis of the proliferation-associated protein Ki-67, the expression of which decreased during aging in tissue-specific cell cultures obtained...
View ArticleEffects of Geroprotectors on Age-Related Changes in Proteolytic Digestive...
We studied the effect of melatonin and epithalon on age-related changes in proteolytic digestive enzyme activity in the pancreas and gastric mucosa of rats kept under different lighting conditions. In...
View ArticlePeptides Restore Functional State of the Kidneys During Cisplatin-Induced...
The effects of polypeptide complex from the kidney and short peptides AED, EDL, and AEDG on renal functions were studied in rats with cisplatin-induced acute renal failure. AED peptide decreased...
View ArticleShort Biologically Active Peptides as Epigenetic Modulators of Gene Activity
AbstractShort (2–4 aa) peptides investigated increased life span of rats and improved various physiological functions and health status in aged people. Biological activities of peptides are tissue...
View ArticleShort Peptides and Telomere Length Regulator Hormone Irisin
Irisin produced by muscles during exercise and promoting fat burning also exhibits geroprotective effect and induces telomere elongation in normal somatic cells. Special attention is paid to studies of...
View ArticleGDF11 protein as a geroprotector
AbstractGDF11 protein, the growth differentiation factor 11, which belongs to the TGF-β superfamily (transforming growth factor β), shows marked geroprotective effects on the cardiovascular and nervous...
View ArticlePeptide Regulation of Skin Fibroblast Functions during Their Aging In Vitro
The effect peptides KE, KED, AED and AEDG on proliferation (Ki-67), regeneration and aging (CD98hc), apoptosis (caspase-3), and extracellular matrix remodeling (MMP-9) in skin fibroblasts during their...
View ArticleEffects of Vascular Peptide Bioregulator on the Density of Microvascular...
Using a TV unit for microcirculation studies, we studied the density of the entire microvascular network and its arterial compartment in the pia mater of the sensorimotor cortex in intact young and...
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